False-Negative Results from Point-of-Care Qualitative Human Chorionic Gonadotropin (hCG) Devices Caused by Excess hCGβ Core Fragment Vary with Device Lot Number

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منابع مشابه

Point-of-care and over-the-counter qualitative human chorionic gonadotropin (hCG) devices remain susceptible to false-negative results caused by excess hCG β core fragment.

Employment or Leadership: None declared. Consultant or Advisory Role: None declared. Stock Ownership: None declared. Honoraria: None declared. Research Funding: Bio-Rad Laboratories, ddPCR Reagents, Life Technologies, Acrometrix inhibition panel; K.R. Jerome, Bio-Rad Laboratories. Expert Testimony: None declared. Patents: None declared. Other Remuneration: T.C. Dingle, Bio-Rad Laboratories prov...

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Screening method to evaluate point-of-care human chorionic gonadotropin (hCG) devices for susceptibility to the hook effect by hCG β core fragment: evaluation of 11 devices.

BACKGROUND The predominant hCG variant in urine, hCG β core fragment (hCGβcf), has been demonstrated to cause false-negative results in qualitative point-of-care (POC) hCG devices. This is a major concern for healthcare professionals using POC pregnancy tests. We developed a screening method to evaluate qualitative POC hCG devices for their susceptibility to inhibition by hCGβcf. Using this met...

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Human chorionic gonadotropin (hCG) versus magnesium sulfate to arrest preterm

Introduction: Considering the high incidence of preterm labor and its known complications, and that human myometrium contains receptors for human chronic gonadotropin (hCG) and that hCG can inhibit myometrial contractions on vitro, made me study treating effects of hCG on preterm labor. This clinical trial study was carried out to compare the effect of hCG, and magnesium sulfate (mgso4) on pre...

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Interaction of human chorionic gonadotropin (hCG) and asialo-hCG with recombinant human thyrotropin receptor.

hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma cell line (HTC) lacking endogenous TSHr with the full-length cDNA of the hTSHr. Unlike the wild type, the transfected cells, termed HTC-TSHr c...

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Qualitative point-of-care human chorionic gonadotropin testing: can we defuse this ticking time bomb?

Qualitative point-of-care (POC) human chorionic gonadotropin (hCG) testing is routinely performed on urine samples obtained in the Emergency Department (ED) or before surgery to rule out pregnancy and prevent fetal injury or death. Because potentially harmful treatments are allowed to proceed on the basis of a negative hCG test result, falsenegative results can have disastrous consequences. We ...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 2009

ISSN: 0009-9147,1530-8561

DOI: 10.1373/clinchem.2009.133280